Neurodynamics analysis of cochlear hair cell activity
نویسندگان
چکیده
منابع مشابه
Cochlear outer hair cell motility.
Normal hearing depends on sound amplification within the mammalian cochlea. The amplification, without which the auditory system is effectively deaf, can be traced to the correct functioning of a group of motile sensory hair cells, the outer hair cells of the cochlea. Acting like motor cells, outer hair cells produce forces that are driven by graded changes in membrane potential. The forces dep...
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In the inner ear, sensory hair cells not only detect but also amplify the softest sounds, allowing us to hear over an extraordinarily wide intensity range. This amplification is frequency specific, giving rise to exquisite frequency discrimination. Hair cells detect sounds with their mechanotransduction apparatus, which is only now being dissected molecularly. Signal detection is not the only r...
متن کاملIntegration of outer hair cell activity in a one-dimensional cochlear model.
Recently, significant progress has been made in understanding the contribution of the mammalian cochlear outer hair cells (OHCs) to normal auditory signal processing. In the present paper an outer hair cell model is incorporated in a complete, time-domain, one-dimensional cochlear model. The two models control each other through cochlear partition movement and pressure. An OHC gain (gamma) is d...
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Technologies such as hearing aids and cochlear implants do provide useful benefit to a large number of individuals with hearing loss, but they are incapable of truly “correcting” a hearing loss. In contrast to these, replacement of hair cells via stem cell therapies holds promise for a cure. Despite the discovery of stem/ progenitor cells in the mammalian cochlea, no regeneration of either dama...
متن کاملA model of cochlear mechanics with outer hair cell motility.
The outer hair cell (OHC) is known to have the ability to change its length in response to voltage changes across its membrane. The apparent function of this OHC motility is to enhance the tuning of the basilar membrane. The model presented in this paper represents the displacement-to-voltage and voltage-to-displacement transducers of the OHC explicitly, each as low-pass filter functions. The m...
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ژورنال
عنوان ژورنال: Theoretical and Applied Mechanics Letters
سال: 2020
ISSN: 2095-0349
DOI: 10.1016/j.taml.2019.06.007